The makers of Hydrelle claim that the dermal filler injection is around half the size of a typcial filler injection. This means that fewer injections will be needed around a wrinkle site. Hydrelle is also the first dermal filler that combines hyaluronic acid with lidocaine anaesthetic meaning the injections are made less painful and the overall procedure is more comfortable for the patient.

The price tag for Hydrelle is also cheaper than other dermal filler alternatives therefore may be a good option for those looking for a cheaper alternative to fillers such as Juvederm or Restylane with results that last just as long, if not longer.

As with many other fillers, Hydrelle’s side effects can include swelling, redness, tenderness and bruising around the injection site.

Editor’s Note: Since publishing this article, there appears to be a lot of evidence that many women are experiencing severe side effects from their Hydrelle injections. We strongly recommend that anyone thinking of using this dermal filler does their research thoroughly before choosing what dermal filler to have.

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Using data from the human genome project, a team of scientists led by Procter & Gamble have found approximately 1,500 genes that govern wrinkles. The team also believe that they have pinpointed either major causes of aging skin.

The best anti-ageing products currently on the market tend to do little to actually stop or reverse the anti-ageing process. Instead, they tend to plump up the skin or help smooth the appearance of wrinkles. However with the discovery of the genes that help control how soon people will get wrinkles it is hoped that ageing itself will soon be tackled head on.

It appears that some of the ‘well known’ beauty secrets hold true: Wrinkles and ageing is partly down to environment and partly down to genes. The key factors that the team have identified are:

• Hydration: The research team believe that the way that the skin collects and holds on to water is one of the key ageing processes. As the skin ages, the genes that control this process may become less active. The skin will then retain less moisture and this leads to wrinkles.
• Collagen: As we get older, the genes that degrade collagen may become more active and this may cause more wrinkles in the skin. There are currently thought to be about 40 genes involved in the lessening of collagen over time.
• Inflammation: There are around 400 genes that have been identified with inflammation in the skin. These tend to become more active with age, thus creating more wrinkles.
• Antioxidants: Around 200 genes are thought to help control the skin’s defence against free radicals. Age weakens these defences and this can help cause wrinkles.
• Photo-Ageing: Sunlight speeds up the natural ageing process. Sunlight may also damage the genes involved in keeping the skin healthy and this may help cause wrinkles.

By identifying some of the genes that cause ageing – more specifically wrinkles – researchers hope that they will be able to create drugs that will be able to stimulate helpful genes are suppress others to help stop the ageing process or even help restore more youthful skin.

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Ever since Efudix has been used there has been anecdotal evidence about it’s anti-ageing properties. Researchers from the University of Michigan decided to study Efudix in an attempt to discover whether the cream did actually hold anti-wrinkle properties or not.

The team looked at a group of twenty-one 56-85 year olds who were all being treated for actinic keratoses (a precancer usually found on the face, neck and forearms). Each of the patients in the group used Efudix twice daily for six months. Once the six months was up, the researchers compared their skin with their skin before the treatment.

The results have been published in the Archives of Dermatology and shows that te researchers found that the patients had softer skin with improved texture and fewer wrinkles, as well as no precancerous cells. The skin was also said to be more toned, less yellow with discolorations such as brown spots reduced.

Efudix cream costs around £18 for a 20g tube. However it will cause the skin to be quite raw and red. In some patients, the cream will causes high levels of irritancy, so much so that some people may not wish to use the cream.

Efudix cream works by peeling away the surface of the skin, a similar sort of technique to laser skin resurfacing. Any wrinkles which are caused by sun damage should be lessened once the cream has been applied, however the cream will have little effect on deep-set wrinkles not caused by the sun.

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Made from a mixture of hyularonic acid and collagen, the new biodegradable wrinkle fillers are said to have a reduced risk of allergic reactions because their component parts are absorbed by the body at a slower rate. For some patients, the results from these biodegradable wrinkle fillers may be significantly better than the results they could achieve with the more conventional fillers.

There are plenty of ways that the new fillers can be used – from filling out hollow cheekbones, to augmenting the cheeks and lips, or helping to tighten up sagging skin around the eyes and jaw.

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